To create an Auto-Responder in SmarterMail:

1. Login to the web interface as a User through URL :

2. Click on the "Option" button(no. 1) to expand the drop down and click on the "Settings" icon(no. 2).

3. At the left action panel click on "Autoresponder".

4. On the "Options" tab at the right action panel click on "Enable Autoresponder" to activate it 

5. Get to the editor side to add in your text as per below:-

6. Enter a Subject such as Vacation or Out of the Office and Click save to complete the process.